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2005| May | Volume 59 | Issue 5
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Indigenous recombinant streptokinase Vs natural streptokinase in acute myocardial infarction patients: Phase III multicentric randomized double blind trial
SK Diwedi, JS Hiremath, PG Kerkar, Krishna N Reddy, CN Manjunath, SS Ramesh, S Prabhavati, M Dhobe, Kavita Singh, P Bhusari, Raman Rao
May 2005, 59(5):200-207
Streptokinase is the most widely used thrombolytic agent and can now be made using recombinant DNA technology. The present trial was initiated to assess an indigenous recombinant streptokinase (Shankinase, r-SK).
To compare the efficacy and safety of indigenous recombinant streptokinase (Shankinase, r-SK) and natural streptokinase (Streptase, n-SK).
Settings and Design:
Double blind, randomized, non-inferiority, multicentric, parallel study.
Materials and Methods
: Patients of AMI < 6 hours of chest pain and 2 mm ST elevation in 2 contiguous chest leads V1- V6 or 1 mm in limb leads were randomized to receive 1.5 miu of either r-SK or n-SK. CK Peaking and decrease of
50% ST segment were used to assess reperfusion.
: Difference in the groups was assessed by chi-square or paired t test as required. Probability value <0.05 was considered significant with 95% confidence interval.
: Overall 150 patients were recruited (96 r-SK group and 54 in n-SK group) and demographic and clinical profile of the groups was comparable. Reperfusion was seen in 68.2% (58) and 69.4% (34) patients in r-SK and n-SK groups respectively. Commonly seen adverse events were fever in 7 (8.5%), hypotension in 3 (3.6%), nausea in 2 (2.4%) patients. Minor bleeding were seen in 4 (4.8%) of patients.
: Indigenous recombinant Streptokinase (r-SK) is as efficacious as natural streptokinase (n-SK) in establishing reperfusion as assessed by non-invasive parameters with comparable side effect profile..
Domestic violence in pregnancy in North Indian women
Anju Huria Khosla, Deepti Dua, Lajya Devi, Shyam Sunder Sud
May 2005, 59(5):195-199
Domestic violence against pregnant women in the Indian context, violence against women is frequently by family members other than the spouse/intimate partner/husband.
To study the incidence of domestic violence in pregnant North Indian women and the demographic features which put women at high risk for domestic violence.
Study design :
A prospective study at the Government Medical College and Hospital, Chandigarh from January 2004 to December 2004.
Nine hundred and ninety-one pregnant women admitted to the pregnant women admitted to the antenatal ward were interviewed.
Test of significance used was Chi-square test. Odds ratio (OR) and 95% confidence interval (CI) was calculated.
The incidence of domestic violence in this study was 28.4%. The violence was more when the husband was educated up to Class 10 level or lower (OR 2.07 (95%) CI 1.54 to 2.79), was habituated to alcohol (OR 2.31 (95%) CI 1 - 71 to 3.11) or to chewing tobacco (OR 2.77 (95%) CI 1.46 to 3.27) or to smoking cigarettes (OR 2.23 (95%) CI 1.59 to 3.11). The incidence of domestic violence was drastically high in women who were socially unsupported (OR 98.9 (95%) CI 43.65 to 235.68). The level of education and employment of the woman had no effect on the incidence of the abuse. The perpetrator of the abuse was the intimate partner (husband) in 48.2%, the husband's mother in 61.3%, and the husband's sister in 22.6%. Most often the abuse was by more than one person.
The incidence of abuse was more when the male partner was less educated or in the habit of taking alcohol, opium or tobacco and in socially unsupported women. The level of education and employment of the woman had no effect on the incidence of abuse
Magnetic resonace appearance of Gall Bladder Ascariasis
Prafull K Arya, Ranjan Kukreti, Muktanjali Arya, Sachida N Gupta
May 2005, 59(5):208-210
Ascariasis is a common disease in many developing countries and is a common cause of biliary and pancreatic diseases in endemic areas. Numerous studies have been published on biliary tract ascariasis. All these have documented ultrasonography as the primary imaging modality for biliary tract ascariasis. Magnetic Resonance Cholangiopancreatography (MRCP) has been the latest entrant for the study of bilary tract. MRCP findings of biliary tract ascariasis have been scarcely documented. MRCP is a unique non-invasive investigation for demonstrating ascariasis in Gall bladder and bilary tract clearly. We present MR appearances of Gall bladder and biliary tract in a proven case of biliary ascariasis.
Diagnosis of depression in general practice
May 2005, 59(5):217-225
Depression is well recognized as a public health problem that usually runs the risk of becoming chronic, disabling and life threatening if left untreated. Unfortunately depression remains largely under diagnosed in primary care although more than one in ten cases seen in primary care suffers from this condition. Primary care physicians are strategically placed to detect and treat depression early and thus contribute in secondary prevention of this disorder. This article highlights the problems in diagnosis, the ways depressed patients present to the clinicians, the diagnostic criteria, the detailed interview techniques to arrive at a diagnosis of depression. The article also offers an outline of management of depression in primary care.
LETTER TO EDITOR
Gentamicin resistance in biofilm producing pseudomonas aeruginosa causing catheter associated urinary tract infections
Ethel Suman, Sini Varghese, Jolly Jose
May 2005, 59(5):214-216
Usefulness of CD45 density in the diagnosis of B-cell chronic lymphoproliferative disorders
Seyyed Hadi Maljaei, Iraj Asvadi-e-Kermani, Jamal Eivazi-e-Ziaei, Alireza Nikanfar, Jalil Vaez
May 2005, 59(5):187-194
Although many B-cell chronic lymphoproliferative disorders (BCLPDs) including B-cell chronic lymphocytic leukemia (B-CLL) have characteristic clinical and biological features, the overlapping morphologic and immunophenotypic profiles of various BCLPDs, is still the main problem.
Our aim was to evaluate the usefulness of CD45 expression in the immunological classification of BCLPDs.
Setting and design:
A prospective study was set in a university hospital to investigate the CD45 intensity, particularly in B-CLL.
MATERIALS AND Methods:
The expression of CD45 in 37 patients with BCLPD including typical B-CLL (Group I), atypical B-CLL and CLL/PLL (II), and hairy cell leukemia (HCL), B-prolymphocytic leukemia (B-PLL), and B-non Hodgkin's lymphoma (B-NHL) as non-CLL BCLPDs (III) and in eight healthy age matched controls (IV) was quantitatively compared by flow cytometric CD45/RALS gating strategy.
The mean, median, and peak channel scores of CD45 obtained for the four groups were compared using one-way analysis of variance test. A P value < 0.05 was to be considered statistically significant.
Lower CD45 density is associated highly with typical CLL and differences between typical CLL and other groups were significant (P<0.001, 0.001, and 0.001). Non-CLL cases had significantly brighter CD45 expression than atypical CLL (P=0.014). No differences were found between normal lymphocytes and non-CLL BCLPD cases.
CD45 is a useful marker, to discriminate the typical CLL from the non-CLL BCLPD and from atypical CLL.
LETTER TO EDITOR
Cutaneous markers in Ochronosis
Jebaraj Isaac, A Rao
May 2005, 59(5):211-213
Pleural empyema due to group a beta-hemolytic streptococci in an adult
Srujana Mohanty, Bimal K Das, Arti Kapil
May 2005, 59(5):213-214
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