Out of 11234 patients reporting to our outdoor during June 2001 to June 2002, 2594 patients (23.09%) had low back pain. 4358 roentgenograms were done in these patients, a mean of 1.68 per patient. These patients were interviewed and their psychosocial and demographic details were compared with 1000 controls who did not have back pain but attended outdoor for other reasons. In the low back pain group, 67% had psychosocial issues, 57% were in blue-collar jobs, 26% had to change/leave their profession, and 38% did not enjoy their present job. All patients had used NSAIDS at some stage of illness and 64% were advised exercises for the back. The comparative figures in control group were 19% with psychosocial issues, 34% in blue-collar jobs (heavy manual workers), 7% had to switch over to new job, 6% did not relish their present job. Hence, it is concluded that along with exercises and NSAIDS, sufficient consideration should be given to short centre-based intensive rehabilitation program followed by a home-based program for chronic low back pain patients.

A retrospective analysis was done of the resistance pattern of urinary tract pathogens isolated over a 4 months period in a tertiary care hospital. There were a total of 871 clinical isolates comprising of 793 gram negative bacilli and 78 gram positive cocci obtained from 5477 consecutive urine samples. Extended spectrum beta lactamase production was observed in 71.5% of the gram negative bacilli; of these 6.18% were also inhibitor resistant. High level aminoglycoside resistance was observed in 70.17% of Enterococcus isolates while methicillin resistance was documented in 23.8% of the Staphylococcus isolates. A high level of resistance was also noted for ciprofloxacin. Multidrug resistance is a common problem in hospitals which emphasizes the need for judicious use of antimicrobial agents and their continuous in vitro monitoring.

The pattern of Vibrio cholerae 01 and 0139 isolates at Indira Gandhi Medical College and Mayo General Hospital, Nagpur from 1993 to 2002 is presented. Emergence of the novel serotype 0139 in 1993 was followed by periods of quiescence and re-emergence. For the first time after 1993, the 0139 isolates out numbered 01 isolates in 2001. The peculiar epidemiological pattern is compared with other reports.

A cross sectional study on immunization coverage in the town of Pilani was conducted and a total of 166 mothers were interviewed using a pre-tested interview schedule/questionnaire on Knowledge, Attitudes, Perceptions and Expectations (KAPE). The results showed that among the 12-24 month old children 50% fully, 31.3% partially and 18.7% not at all immunized. High levels of initial vaccination rates and low levels of OPV3/DPT3 (62.7%) and measles (51.8%) vaccines indicate that completing vaccination schedule needs attention. Almost all the children in the study, 165 out of 166 received two doses of polio vaccine from the Pulse Polio Immunization programme. Majority of the mothers expressed favourable attitudes and satisfaction regarding the programme. Though many were aware of the importance of vaccination in general, specific information about importance of completing the schedule and knowledge about vaccine preventable diseases other than poliomyelities was very limited. Obstacles, misconceptions/beliefs among the mothers of partially immunized children and lack of information among not at all immunized group were the main reasons of non-immunization. The implications of the study are: to enhance the maternal knowledge about the vaccine preventable diseases and importance of completing the immunization schedule through interpersonal mode and to overcome obstacles to immunization such as accessibility and lack of family support.

In the present study, half of the pups of a litter were undernourished by 12 h daily maternal deprivation from day 5 to day 18 postnatal and were subsequently nutritionally rehabilitated. Responses of CNS-acting drugs (morphine analgesia, pentobarbitone sodium hypnosis, haloperidol catalepsy) were studied at the age of day 9, 12 and 18 in maternally deprived and of day 25 in nutritionally rehabilitated new born rats as compared to that of their nourished littermates. The results showed that the response of these CNS-acting drugs was maximum at the age of day 9 postnatal and progressively decreased thereafter as the age of the animal advanced. The responses of these drugs in maternally deprived animals varied on different days of undernourishment as compared to that of their nourished littermates. The responses were significantly less in first half and were significantly more in second half period of undernourishment. The changes observed in the responses of these CNS-acting drugs were directly related to the changes observed in brain serotonin level in maternally deprived and nutritionally rehabilitated new born rats. The present findings suggest that the nature and degree of undernutrition imposed in suckling rats might only produce temporary effects on the response of CNS-actin drugs and on brain serotonin levels which is reversible if undernourished new born rats were nutritionally rehabilitated on an appropriate time of brain development.