http://www.indianjmedsci.org/currentissue.asp Indian J Med Sci 2003 - 57(12) Indian Journal of Medical Sciences Medknow Publications0019-5359 SV Joshi DM Tripathi HL Dhar Original Article Indian Journal of Medical Sciences 2003 57(12):527-534Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/527/11848 http://www.indianjmedsci.org/text.asp?2003/57/12/527/118485712 527 534 http://www.indianjmedsci.org/text.asp?2003/57/12/527/11848 SV Joshi, DM Tripathi, HL Dhar

Indian Journal of Medical Sciences 2003 57(12):527-534

BACKGROUND: More than one antigen has been used for immunotherapy of allergic disorders. So far less than five antigens have been employed with variable results. AIM: To evaluate effect of multiple antigens up to six in the immunotherapy of nasobronchial allergy. SETTING AND DESIGN: Based on clinical history, symptoms present for at least 3 years with set criteria of immunomodulation for asthma and rhinitis: documented IgE mediated asthma and rhinitis, failure in allergen avoidance and moderate to severe clinical manifestations. MATERIAL AND METHODS: Five hundred cases of various allergic disorders attending allergy clinic of Bombay hospital were screened. Allergen specific immunotherapy was initiated in 131 subjects (56 -rhinitis and 75 asthma) with prior consent. Patients suffering from allergic disorders secondary to diseases or drug therapy were excluded. Multiple allergen immunotherapy was given at specific intervals up to a period of one year. Allergen extracts were prepared as per standard technique. For statistical analysis "students't test" was used. RESULTS AND CONCLUSIONS: Significant improvement in PEFR, reduction in skin sensitivity to allergens used in immunotherapy formulation and symptomatic relief without any untoward reaction show that multiple allergen immunotherapy is as effective as monoallergen immunotherapy in nasobronchial allergy.]]> http://www.indianjmedsci.org/text.asp?2003/57/12/527/11848 N Gupta F Khan M Tripathi VP Singh S Tewari V Ramesh N Sinha S Agrawal Original Article Indian Journal of Medical Sciences 2003 57(12):535-42Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/535/11847 http://www.indianjmedsci.org/text.asp?2003/57/12/535/118475712 535 42 http://www.indianjmedsci.org/text.asp?2003/57/12/535/11847 N Gupta, F Khan, M Tripathi, VP Singh, S Tewari, V Ramesh, N Sinha, S Agrawal

Indian Journal of Medical Sciences 2003 57(12):535-42

BACKGROUND: Interaction between various genetic and environmental factors is associated with coronary artery diseases (CADs). Factor V Leiden mutation (FVL) and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis, however, with a doubtful role in coronary artery disease and myocardial infarction. AIM: Present study was conducted to assess the relationship of both these factors in coronary artery disease in population from North India. SETTING AND DESIGN: Case control study. MATERIAL AND METHODS: Two hundred angiographically proven coronary artery disease patients were studied to examine the association of Factor V Leiden mutation and FII G20210A mutation with coronary artery disease and myocardial infarction. Out of 200 patients, 51 had myocardial infarction. Two hundred controls were selected who were from north India and were also age and sex matched. RESULTS AND CONCLUSIONS: Our results indicate that both these polymorphisms were totally absent in our population, therefore, these variants cannot be considered as independent risk factors or as a predictor for CAD. However, there is a need to confirm the above findings on patients from different populations from different parts of the country as there are reports which show that the incidence of Factor V Leiden varies from 1.3 % to 10%.]]> http://www.indianjmedsci.org/text.asp?2003/57/12/535/11847 O Tiryakioaylu P Kadiolgu NU Canerolgu H Hatemi Original Article Indian Journal of Medical Sciences 2003 57(12):543-548Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/543/11846 http://www.indianjmedsci.org/text.asp?2003/57/12/543/118465712 543 548 http://www.indianjmedsci.org/text.asp?2003/57/12/543/11846 O Tiryakioaylu, P Kadiolgu, NU Canerolgu, H Hatemi

Indian Journal of Medical Sciences 2003 57(12):543-548

BACKGROUND: Serum levels of insulin-like growth factor-1 (IGF-1) reflect endogenous growth hormone (GH) secretion in healthy subjects. Measurements of IGF-1 are useful for diagnosis and follow-up of patients with acromegaly and the diagnosis of GH deficiency in children. AIMS: To assess age dependency and normal ranges of serum IGF-1 levels in healthy Turkish population. SETTING AND DESIGN: We therefore studied 272 healthy adolescents and adults between 15-75 years of age. None had diabetes or other endocrine disease or had received estrogen therapy. MATERIAL AND METHODS: Height, weight, body mass index (BMI) and waist-hip ratio were measured in all subjects. Serum samples were obtained during morning hours and IGF-1 was measured by radioimmunoassay. STATISTICAL ANALYSIS: The age-dependent reference range for serum IGF-1 concentrations was calculated by simple least linear regression analysis: the regression line represents the means with 95 percent confidence intervals. Correlation analysis was also done. RESULTS: Ageing was negatively related to serum levels of IGF-1 (P= 0.0001, r=-0.931) with a mean decrease (youngest vs. oldest). IGF-1 levels increased during adolescence, with the highest mean values during puberty. After puberty, a subsequent decline in serum levels of IGF-1 was apparent. There were also a significant difference according to gender; females had significantly higher levels (357.909+/-219.167 mg/L) than males (307.962+/-198.41 mg/L) (P=0.012). IGF-1 levels were correlated with body height (P=0.001, r=0.223), body weight (P=0.002,r=-0.188) and BMI (P=0.039, r=0.128). CONCLUSION: IGF-1 serum levels increase in adolescents with a peak in puberty, whereafter IGF-1 levels return to prepubertal levels.]]> http://www.indianjmedsci.org/text.asp?2003/57/12/543/11846 M Malhotra JB Sharma S Batra R Arora S Sharma Original Article Indian Journal of Medical Sciences 2003 57(12):549-555Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/549/11845 http://www.indianjmedsci.org/text.asp?2003/57/12/549/118455712 549 555 http://www.indianjmedsci.org/text.asp?2003/57/12/549/11845 M Malhotra, JB Sharma, S Batra, R Arora, S Sharma

Indian Journal of Medical Sciences 2003 57(12):549-555

BACKGROUND: Pelvic inflammatory disease is a common problem faced by the gynecologists in there out patient department. AIM: The aim of the study was to evaluate the efficacy of three treatment combinations in the syndromic management of pelvic inflammatory disease in the out patient setting. SETTING DESIGN: In the medical college hospital patients presenting in gynecology out patient department were enrolled. MATERIAL AND METHODS: One hundred and sixty five women with diagnosis of pelvic inflammatory disease were randomized into three equal groups getting ciprofloxacin (500 mg) and tinidazole (600 mg) combination twice daily for 7 days (Group 1), a kit containing fluconazole (150 mg), azithromycin (1 gm) and secnidazole (2 mg) as one time dose (Group 2) and Doxycycline 100mg twice daily and metronidazole 200 mg thrice daily for seven days (Group 3). Severity score was determined on first visit and after 1 week and 4 weeks when patients were called for follow up. Statistical Analysis: Chisqare test, Krusker wallis test and Mann Whitney test. RESULTS: There was significant reduction in severity score after 1 week of treatment, which was further reduced after 4 weeks in all the three groups. Cure rate was highest in-group 1 (96%) followed by group 2 (93.5) and group 3 (91.3%) but the difference was not statistically significant. Resolution of inflammatory mass was highest in group 1. The incidence of side effects was highest and compliance was lowest in the doxycycline -metronidazole group, but the difference was not statistically significant. CONCLUSION: All the three treatment combinations were found to be equally effective in the syndromic management of pelvic inflammatory disease.]]> http://www.indianjmedsci.org/text.asp?2003/57/12/549/11845 RC Parmar SB Bavdekar P Sira JR Kamat Case Report Indian Journal of Medical Sciences 2003 57(12):556-558Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/556/11844 http://www.indianjmedsci.org/text.asp?2003/57/12/556/118445712 556 558 http://www.indianjmedsci.org/text.asp?2003/57/12/556/11844 RC Parmar, SB Bavdekar, P Sira, JR Kamat

Indian Journal of Medical Sciences 2003 57(12):556-558

A few cases of necrotizing myelitis have been reported in adults since its first description in 1973. No case has been described in the pediatric age group. A 12-year-old boy, who presented with acute flaccid paraplegia, loss of sphincter control and sensory loss showed features suggestive of necrotizing myelitis on magnetic resonance imaging. Investigations carried out could not reveal a specific etiological or pre-disposing factor. No clinical improvement occurred despite the therapy.]]> http://www.indianjmedsci.org/text.asp?2003/57/12/556/11844 OP Jhirwal S Chakrabarti Letter To Editor Indian Journal of Medical Sciences 2003 57(12):559-560Indian Journal of Medical Sciences http://www.indianjmedsci.org/text.asp?2003/57/12/559/11843 http://www.indianjmedsci.org/text.asp?2003/57/12/559/118435712 559 560 http://www.indianjmedsci.org/text.asp?2003/57/12/559/11843 OP Jhirwal, S Chakrabarti

Indian Journal of Medical Sciences 2003 57(12):559-560

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