Indian Journal of Medical Sciences : 1998 - 52(5)

Human leucocytic antigens (HLA) in breast cancer.

BM Biswal

BM Biswal, R Kumar, PK Julka, U Sharma, MC Vaidya

Indian Journal of Medical Sciences 1998 52(5):177-83

HLA frequencies of fifty (50) female breast cancer patients were compared with 200 age matched female controls. A total of 20 HLA-A locus, 35 HLA-B locus and 8 HLA-C locus antigens were studied. The HLA-A2, A11, Aw19 and A30; HLA-B8, B14 and HLA Cw6 were found significantly higher than the controls. The HLA-A11, HLA-Aw19 and HLA-B8 were found protective whereas, HLA-A2, HLA-B14 and HLA-Cw6 were a risk for breast cancer. The prective antigens' probable involvement through immunogenic mechanism in breast cancer is emphasized in this article.

Copper and ceruloplasmin levels in serum of women with breast cancer.

SM Vaidya

SM Vaidya, PL Kamalakar

Indian Journal of Medical Sciences 1998 52(5):184-7

40 cases of breast malignancy constituted the study group and 10 sex matched formed the control grp. Serum level of copper was estimated by atomic absorption photometry and ceruloplasmin was done by Houchin's method. The study group showed significant hypercupremia and increased level of serum ceruloplosmin. It was postulated that levels copper and ceruloplasmin may help in prognosis & diagnosis of disease.

Left ventricular mass index in patients of end stage renal disease (non-diabetic) on regular haemodialysis.

VS Kumar

VS Kumar, SK Babu, BS Kumar, RP Singh

Indian Journal of Medical Sciences 1998 52(5):188-90

Echocardiography in patients of end stage renal failure (non diabetic) on regular haemodialysis revealed increase in left ventricular mass index in comparison to healthy controls. Anaemia, chronic uraemic state and hypertension were the probable contributory factors.

Serum cholesterol in healthy postmenopausal women.

BB Samanta

BB Samanta

Indian Journal of Medical Sciences 1998 52(5):191-5

Hypercholes erolaemia is a modifiable risk factor in atherosclerosis. Women lose their relative protection against coronory heart disease at menopause because of changed lipid profile due to oestrogen deficiency. Total serum cholesterol was estimated in 82 healthy postmenopausal women in the age group of 46-72 years (51.5 +/- 7.39). Thirty five healthy pre-menopausal women in the age group of 18-38 years (29.5 +/- 6.4) served as controls. The mean serum cholesterol concentration was significantly higher in the postmenopausal group compared to control group (178.5 +/- 39.8 Vs 155.4 +/- 24 mg/dl; P < 0.01). Serum cholesterol concentration in the study group was not related to social class, dietary habit and obesity.

Effects of spinal anaesthesia on metabolic processes.

D Shende

D Shende, S Sharma, S Kaushik

Indian Journal of Medical Sciences 1998 52(5):196-200

A study conducted at P.G.I., Chandigarh to find out the effect of spinal anaesthesia on arterial blood gases, blood glucose, and pyruvate-lactate during spinal anaesthesia. All patients received night sedation of oral diazepam in dose of 0.2 mg/kg body weight. No narcotic/antisialogogue premedication was given to any patient. All patients received spinal anaesthesia with 5% lignocaine (hyperbaric), in lateral position. All patients received normal saline intravenously as a maintenance fluid. Blood samples for the measurement of blood pyruvate, lactate levels and arterial blood gas analysis were collected preoperatively, 10 minutes after the administration of spinal anaesthesia after fixation of drug, and half hour after the end of operative procedure. Even though there was continued rise in blood sugar levels intraoperatively, which persisted in postoperative period, the values were within normal clinical range. Blood lactate levels and blood pyruvate levels remained unchanged. Hypocapnoea observed intra-operatively in our report is attributed to hyperventilation. There was 12.44% fall in bicarbonate level. (P > .001) which even though statistically significant did not alter the pH. We conclude that spinal anaesthesia up to T8 level does not affect the metabolic processes.

Case report of Balantidium coli in human from south of Tehran, Iran.

F Maleky

F Maleky

Indian Journal of Medical Sciences 1998 52(5):201-2

A Patient with Balantidiasis in an urinary bladder is reported. Trichomonas vaginalis were identified and no other cause of the haematuria was apparent. This condition didn't common and may be linked to ectopic Balantidium in urinary bladder.

Ulcerative tonsillopharyngitis due to arcanobacterium haemolyticum--a case report.

NA Ambhore

NA Ambhore, SV Jalgaonkar, RP Fule

Indian Journal of Medical Sciences 1998 52(5):203-4

Antioxidant property of Saffron in man.

SK Verma

SK Verma, A Bordia

Indian Journal of Medical Sciences 1998 52(5):205-7

50 mg of Saffron dissolved in 100 ml of milk was administered twice a day to 20 human subjects. Lipoprotein oxidation susceptibility (LOS) was estimated initially and after 3 and 6 weeks. There was a constant decrease in LOS during this period. From a mean of 66.4 +/- 3.18 it decreased to 38.3 +/- 2.8 in 10 healthy individuals and from 76.0 +/- 3.72 to 48.8 +/- 3.0 in 10 patients of CAD. The significant fall (P < 0.001) in LOS indicates the potential of Saffron as an antioxidant.