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A simplified acute physiology score in the prediction of acute aluminum phosphide poisoning outcome
Shahin Shadnia1, Omid Mehrpour2, Kambiz Soltaninejad3
1 Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Faculty of Medicine, and Toxicological Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Forensic Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3 Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran
Correspondence Address:
Kambiz Soltaninejad
Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization of Iran, Behesht Street, Khayam Avenue, Tehran-11144
Iran
Background : Aluminum phosphide (AlP) is used as a fumigant. It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for AlP intoxication, and also, there are few data about its prognostic factors. AIMS: The aim of this study was to determine the impact of the Simplified Acute Physiology Score II (SAPS II ) in the prediction of outcome in patients with acute AlP poisoning requiring admission to the Intensive Care Unit (ICU). Materials and Methods : This was a prospective study in patients with acute AlP poisoning, admitted to the ICU over a period of 12 months. The demographic data were collected and SAPSII was recorded. The patients were divided into survival and non-survival groups due to outcome. Statistical Analysis : The data were expressed as mean ± SD for continuous or discrete variables and as frequency and percentage for categorical variables. The results were compared between the two groups using SPSS software. Results : During the study period, 39 subjects were admitted to the ICU with acute AlP poisoning. All 39 patients required endotracheal intubation and mechanical ventilation in addition to gastric decontamination with sodium bicarbonate, permanganate potassium, and activated charcoal, therapy with MgSO 4 and calcium gluconate and adequate hydration. Among these patients, 26 (66.7%) died. SAPSII was significantly higher in the non-survival group than in the survival group (11.88 ± 4.22 vs. 4.31 ± 2.06, respectively) (P < 0.001). Conclusion : SAPSII calculated within the first 24 hours was recognized as a good prognostic indicator among patients with acute AlP poisoning requiring ICU admission.
How to cite this article:
Shadnia S, Mehrpour O, Soltaninejad K. A simplified acute physiology score in the prediction of acute aluminum phosphide poisoning outcome.Indian J Med Sci 2010;64:532-539
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How to cite this URL:
Shadnia S, Mehrpour O, Soltaninejad K. A simplified acute physiology score in the prediction of acute aluminum phosphide poisoning outcome. Indian J Med Sci [serial online] 2010 [cited 2013 Jun 19 ];64:532-539
Available from: http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2010;volume=64;issue=12;spage=532;epage=539;aulast=Shadnia;type=0 |
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