Scientists at Stanford University for Medicine have now decoded a connection between caffeine consumption and advancing age, cardiovascular disease and inflammation.
Through the study of family histories, survey data and blood samples from nearly 100 participants in a multi-year research, scientists have uncovered a basic inflammatory mechanism responsible for aging and chronic ailments.
This research study was published recently in Nature Medicine and according to the paper, the inflammatory process is just as responsible for mortality as it is for cardiovascular diseases. As nucleic acid breaks down, they circulate through the blood and cause inflammations.
In these studies, it was also seen that caffeine and the metabolites it has might just be capable of countering this nucleic acid situation. Probably another reason why coffee drinkers live longer than those who do not.
David Furman, PhD, recently said that nearly all of noncommunicable diseases that come from age are because of chronic inflammation. Alzheimer’s disease, cancers, dementias, osteoarthritis, cardiovascular disease and many forms of depression all occur because of inflammations that occur non-stop. He also says that evidence is now amassing that suggests coffee to be an inhibitor for such chronic inflammations.
The link between coffee and reduced inflammatory mechanism came to the forefront when data analysis revealed that of all older participants in the study, those who regularly indulged in caffeinated drinks had reduced occurrence. The specific program that led to this discovery was the Stanford-Ellison cohort, which began a decade ago. This program included participants between the age group of 20 and 60 who were periodically asked for blood samples, medical histories and more.
The research revealed that there were only two clusters of genes that were responsible for production of the circulating inflammatory protein. When participants were compared, they observed that those with high activation of these two clusters had a higher chance to get health complications. In the study itself 9 of the high activation participants had blood pressure issues whereas among the older participants with low activation of the two gene clusters, only one had blood pressure issues.
Yet another indication of coffee and the gene cluster responsible for the inflammatory protein IL-1-beta is that in the low group it was eight times as likely that a participant had a relative who lived to the ripe old age of 90.
All this because coffee has some sort of inhibitory function on the gene clusters responsible for producing IL-1-beta protein.