| CASE REPORT |
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| Year : 2010 | Volume
: 64
| Issue : 1 | Page : 41-44 |
Application of autologous bone marrow stem cells in giant axonal neuropathy
Alok Sharma1, Nandini Gokulchandran1, Pooja Kulkarni2, Guneet Chopra1
1 Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Mumbai, India
2 Department of Research and Development, NeuroGen Brain and Spine Institute, Mumbai, India
Correspondence Address:
Guneet Chopra
Head, Research and Development, NeuroGen Brain and Spine Institute, Basement of Surana Sethia Hospital and Research Centre, Sion-Trombay Road, Chembur, Mumbai - 400 071
India
DOI: 10.4103/0019-5359.92487 PMID: 22301809
Giant axonal neuropathy is a rare disorder of autosomal recessive inheritance, morphologically characterized by accumulation of neurofilaments in enlargements of preterminal regions of central and peripheral axons. We present a 7-year-old girl with thick and tightly curled lackluster hair suffering from giant axonal neuropathy. The diagnosis was confirmed on the brain MRI which showed white matter abnormalities in the anterior and posterior periventricular regions as well as the cerebellar white matter. In view of the same, the patient was given intrathecal autologous bone marrow-derived stem cell therapy as part of the neuroregenerative rehabilitation therapy protocol. The patient showed functional improvements in her disability after receiving the therapy. A detailed case report is presented here with.
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