| ORIGINAL CONTRIBUTION |
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| Year : 2009 | Volume
: 63
| Issue : 2 | Page : 66-71 |
Prevalence and extent of glycemic excursions in well-controlled patients with type 2 diabetes mellitus using continuous glucose-monitoring system
Shokoufeh Bonakdaran, Reza Rajabian
Mashhad University of Medical Science, Endocrine Research Center, Ghaem Hospital, Mashhad, Iran
Correspondence Address:
Shokoufeh Bonakdaran
Endocrine Research Center, Faculty of Medicine, Ghaem Hospital, Mashhad
Iran
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DOI: 10.4103/0019-5359.49237 PMID: 19359769
Background : Continuous glucose-monitoring system (CGMS) is a tool for assessment of glycemic excursions. Glucose variability is a risk factor independent of glycosylated hemoglobin (HbA1c) for diabetic complications; hence CGMS may be a better method for management of diabetes. Aim: To evaluate the extent of glycemic excursions in well-controlled type 2 diabetic patients. Setting and Design :The study was carried out in 21 diabetic patients on oral agents. Materials and Methods: Patients underwent continuous glucose-monitoring by CGMS for 3 days. Number and duration of glycemic excursions, correlation coefficient (%) between CGMS and self-monitoring blood glucose (SMBG), mean absolute difference (%MAD) and complications of CGMS were analyzed. Statistical Analyses : The statistical analyses were performed with the use of mean ± SD, t-test and Mann-Whitney test. Results :The mean age of patients was 51.9 ± 9.7 years. The mean HbA1c was 6.7 ± 0.38%. The mean number of glycemic readings was 753.6 ± 203.5 times. The correlation coefficient was 0.83 and the MAD was 11.7 ± 8.0%, which were considerable. Three (14.2%) patients experienced, altogether, 9 hypoglycemic events with an average duration of 162 minutes. Twenty (94.7%) patients had hyperglycemic events. The mean duration of hyperglycemia was 19.4 ± 12.8 hours. All events were asymptomatic. Disconnection of device was the most common complication (3 patients). Conclusion : This study demonstrated that well-controlled type 2 diabetic patients have a considerable number of hypoglycemia and hyperglycemia events that may be missed by SMBG.
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