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LETTER TO EDITOR
Year : 2006  |  Volume : 60  |  Issue : 7  |  Page : 297-299
 

Seroprevalance of toxocara antibodies in multiple sclerosis and ankylosing spondylitis


1 Department of Parasitology, Firat University, Faculty of Medicine, Elazig, Turkey
2 Division of Rheumatology, Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, Elazig, Turkey
3 Division of Neurology, Firat University, Faculty of Medicine, Elazig, Turkey

Correspondence Address:
Salih Kuk
Firat University, Department of Parasitology 23119, Elazig
Turkey
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DOI: 10.4103/0019-5359.26605

PMID: 16864915

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How to cite this article:
Kuk S, Ozgocmen S, Bulut S. Seroprevalance of toxocara antibodies in multiple sclerosis and ankylosing spondylitis. Indian J Med Sci 2006;60:297-9

How to cite this URL:
Kuk S, Ozgocmen S, Bulut S. Seroprevalance of toxocara antibodies in multiple sclerosis and ankylosing spondylitis. Indian J Med Sci [serial online] 2006 [cited 2014 Aug 21];60:297-9. Available from: http://www.indianjmedsci.org/text.asp?2006/60/7/297/26605


Sir,

Multiple sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system. Its etiology remains obscure and subject to extensive research. Although some studies have shown an association between contact with a dog or cat and MS, the role of this contact in the etiology of the disease is still unclear. Ankylosing spondylitis (AS) is a chronic inflammatory disease that predominantly affects young male individuals. The etiology of AS has not been completely clarified. However, a close association with HLA B27 has been shown.

Toxocariasis is a common infection worldwide. Humans acquire the infection by oral ingestion of the Toxocara eggs through contact with larvae contaminating the teats of bitches or by the consumption of raw or not adequately cooked paratenic host. Toxocara canis is the cause of toxocariasis in humans and causes at least three syndromes: visceral larva migrans, ocular larva migrans and covert toxocariasis. In addition, the question was raised whether an autoimmune phenomenon was involved in Toxocara infections.[1],[2],[3] The aim of this study was to assess the seroprevalance of Toxocara antibodies in MS and AS, two different diseases with unknown etiology.

Thirty-seven patients (14 male and 23 female) who were followed by the Multiple Sclerosis Outpatients Clinic and Physical Medicine and Rehabilitation Department and had clinically definite MS, were enrolled. Thirty-one patients (24 male, 7 female) who met the modified New York criteria for the diagnosis of AS, were included in the study. The study group was recruited from the patients attending the rheumatology outpatients clinic of our institution. We compared the patient's results with our cohort consisting of 50 healthy subjects (25 male, 25 female) who were living in our city.[4] Informed consent of all the patients participating in the study was obtained. Specific anti- Toxocara IgG or M antibodies were determined by enzyme-linked immunosorbent assay (ELISA) (Novum Diagnostica, Germany), according to the manufacturer's instructions. Statistical analyses were performed using the statistical package for social sciences (SPSS) software.

We found 10.8% Toxocara seropositivity among the MS cases and 3.2% Toxocara seropositivity among the AS cases. For MS patients, the odds ratio was 5.94 and the 95% confidence interval was 0.64 to 55.53, with a P -value of 0.08. The odds ratio of MS between those with toxocara seropositivity was more than five times higher than among those with toxocara seronegativity. For AS patients, the odds ratio was 1.63 and the 95% confidence interval was 0.10-27.10, with a P -value of 0.73. There was no significant difference in Toxocara seropositivity between our control population with MS and with AS patients. Demographic data and seropositivity in patients and healthy controls is shown in [Table - 1]. Twenty-eight patients (75.6%) of MS had relapsing-remitting, 1 (2.7%) had primary progressive and 8 (21.6%) had secondary progressive disease. Two patients with MS who had relapsing-remitting disease and two patients with secondary progressive MS were Toxocara seropositive. Only one AS patient was Toxocara seropositive and had axial involvement without extraarticular features.

Toxocara canis is a worldwide common parasite and its frequency ranges between 2.6 and 47.5% in the adult urban population. Dogs and cats are important in the life cycle of T oxocara and owning dogs and cats is a risk factor for Toxocara infection. In a recent study, contamination of playgrounds by Toxocara spp. was found to be relatively lower than other cities in our country, as seen in our study also.[4] Toxocara seroprevalance has been widely investigated in diseases of unknown etiology. It has been hypothesized that T oxocara could have etiological importance in MS.[3] In our study, all patients with MS and AS were adults and most of the patients with MS were females (62.1%), whereas most of the patients with AS were males (77.4%). This was not considered as a limitation for the study, since it has been shown that gender and age did not influence Toxocara seropositivity.[5]

There are some limitations in this study. Firstly, whether the infection was causing the disease or whether the disease was causing the infection, was unclear. Secondly, we could not conduct a regression analysis on the gender effect and other factors, since the sample size was small. To our knowledge, this is the first report assessing Toxocara seropositivity in patients with MS and AS, as compared to the healthy control population. Further research with a wide series of MS patients is warranted.

 
 ¤ References Top

1.Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology and molecular aspects. Clin Microbiol Rev 2003;16:265-72.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Garcia LS. Tissue Nematodes. Diagnostic Medical Parasitology. 4th ed, ASM press: Washington DC; 2001. p. 309-12.  Back to cited text no. 2    
3.Sondergaard HP, Theorell T. A putative role for Toxocara species in the aetiology of multiple sclerosis . Med Hypotheses 2004;63:59-61.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Kuk S, Özel E, Oguztürk H, Kirkil G, Kaplan M. Seroprevalance of Toxocara antibodies in patients with adult asthma. Southern Med J In press.  Back to cited text no. 4    
5.Chia KF, Chien CH, Wen YD, Chien WL, Kua ES. Seroepidemiolgy of Toxocara canis infection among mountain aboriginal schoolchildren living in contaminated districts in eastern Taiwan. Trop Med and Int Health 2004;9:1312-8.  Back to cited text no. 5    


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[Table - 1]

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Korean Journal of Ophthalmology. 2014; 28(3): 207
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