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Year : 2004  |  Volume : 58  |  Issue : 2  |  Page : 67-71

Arthritis in lymphomatoid granulomatosis: Report of a case and review of literature

1 Department of Medicine, Government Medical College & Hospital, Sector 32, Chandigarh, India
2 Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
3 Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Correspondence Address:
Vikas Agarwal
Department of Medicine, C1221, Sector 32B, Chandigarh - 160030
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Source of Support: None, Conflict of Interest: None

PMID: 14993719

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Lymphomatoid granulomatosis (LG) is a rare systemic vasculitis caused by Epstein Barr virus induced transformation of the B-cells in a T-cell rich environment. The predominant clinical presentations are confined to the pulmonary system however; extra-pulmonary manifestations can sometimes be the main feature of the disease. Here in we describe a 52-year-old female who presented with symmetric polyarthritis and generalized stiffness for 7 months and papular lesions over extremities for 3 months duration. She in addition had generalized lymphadenopathy. Histopathological examination of the cutaneous lesions confirmed LG. Patient died despite therapy with cyclophosphamide and prednisolone. This is the first report of LG mimicking rheumatoid arthritis from India.


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© 2004 - Indian Journal of Medical Sciences
Published by Wolters Kluwer - Medknow
Online since 15th December '04