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ORIGINAL CONTRIBUTION |
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| Year : 2000 | Volume
: 54
| Issue : 8 | Page : 339-341 |
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Evaluation of comparative and combined depressive effect of Brahmi, Shankhpushpi and Jatamansi in mice
NH Indurwade, KR Biyani
Sudhakarrao Naik Institute of Pharmacy, Pusad (M.S.) Dist. Yavatamal 445 244, India
Correspondence Address:
N H Indurwade
Sudhakarrao Naik Institute of Pharmacy, Pusad (M.S.) Dist. Yavatamal 445 244
India
PMID: 11143748
How to cite this article:
Indurwade N H, Biyani K R. Evaluation of comparative and combined depressive effect of Brahmi, Shankhpushpi and Jatamansi in mice. Indian J Med Sci 2000;54:339-41 |
How to cite this URL:
Indurwade N H, Biyani K R. Evaluation of comparative and combined depressive effect of Brahmi, Shankhpushpi and Jatamansi in mice. Indian J Med Sci [serial online] 2000 [cited 2013 May 18];54:339-41. Available from: http://www.indianjmedsci.org/text.asp?2000/54/8/339/12172 |
| ¤ Introduction | |  |
In ayurveda, herbal drugs like Bacopa moniera (Brahmi), convolvuFus pluricaulis (Shankhpushpi) and Nardostachys jatamansi (Jatamansi) are used as medicine in the treatment of various mental disorders. They act as tranquilizers and also used in the treatment of hypertension. [1] The present study was aimed to evaluate the comparative effect of individual drug and also their combined effect on the depressive activity in mice.
| ¤ Material and Methods | | |
1. Preparation of aqueous extract [2] 100 G of dried leaves of Brahmi (drug-I) were obtained and boiled with 800 ml of water till 1 /8th of volume were remained. It was then filtered and filterate was concentrated and dried. Similar procedure was adopted for shankhpushpi (drug-II) and Jatamansi (drug-111).
2. Depressive activity [3],[4] For evaluation of depressive activity, Actophotometer was used. To carry out the study, 66 albino mice of either sex weighing between 20t 25 G were taken and divided into different 11 groups comprising 6 mice in each group and were treaded as below, Group I Controlled group (vehicle) Group II, III, IV Received 50, 100 & 200 mg/kg of body weight of drug I Group V, VI, VII Received 50, 100 & 200 mg/kg of body weight of drug II Group VIII, IX. X Received. 50, 100 & 200 mg/kg of body weight of drug III Group XI Received 100 mg/kg of body weight combination of drug I, II&III (1:1:1).
The readings were noted at 30 mins, 60 mins, 90 mins & 120 mins, after intraperitoneal injection of effective drug in respective groups. The standard method for actophotometer was adopted.[5] The observation of autophotometer ± S.D. was noted down (p<0.001).
| ¤ Results and Conclusion | | |
In this present study, lower dose (50 mg/kg) of all three drug extract showed comparatively less depressive effect while at higher doses each drug showed marked depressant activity. The order of potency was found to be:
Jatamansi > Shankhpushpi > Brahmi
The combined extract effect at the dose of 100 mg/kg was found to be more as compared to the respective dose of individual drug extract. At this dose level the order of potency was found to be, Combined extract < Jatamansi > Shankhpushpi > Brahmi
| ¤ Summary | | |
Evaluation of depressive activity of drug extract of Brahmi, Jatamansi & Shankhpushpi and their combined effects were studied on 66 mice of either sex. It was found that combined effect of Jatamansi, Shankhpushpi & Brahmi showed the potent depressiveness in mice. While in individual drug extract, jatamansi exhibited more potent effect than other two drugs.[5] [Table 1],[Figure 1],[Figure 2]
| ¤ References | | |
| 1. | The wealth of India. Publication and Information directorate, CSIR, New Delhi, Vol. II(pp 315): Vol. IV (pp 22), Vol. IV (pp 116).  |
| 2. | Sharangdhar Samhita, Vol 11. Chap. 8. |
| 3. | Lawrence DR, Bacharach AL. Evaluation of drug activities Pharmacometics; Vol I, Academic Press, London. |
| 4. | Turner RA. Screening method in Pharmacology, Vol. I. |
| 5. | Kulkarni SK. Handbook of experimental pharmacology, second edition (1983). |
[Figure 1], [Figure 2]
[Table 1]
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