| CLINICAL TRIAL |
|
| Year : 1998 | Volume
: 52
| Issue : 5 | Page : 177-83 |
Human leucocytic antigens (HLA) in breast cancer.
BM Biswal, R Kumar, PK Julka, U Sharma, MC Vaidya
Radiotherapy Dept, All Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Correspondence Address:
B M Biswal
Radiotherapy Dept, All Institute of Medical Sciences, Ansari Nagar, New Delhi
India
PMID: 9808907
HLA frequencies of fifty (50) female breast cancer patients were compared with 200 age matched female controls. A total of 20 HLA-A locus, 35 HLA-B locus and 8 HLA-C locus antigens were studied. The HLA-A2, A11, Aw19 and A30; HLA-B8, B14 and HLA Cw6 were found significantly higher than the controls. The HLA-A11, HLA-Aw19 and HLA-B8 were found protective whereas, HLA-A2, HLA-B14 and HLA-Cw6 were a risk for breast cancer. The prective antigens' probable involvement through immunogenic mechanism in breast cancer is emphasized in this article.
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