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Year : 1997  |  Volume : 51  |  Issue : 4  |  Page : 118-119

Hepatic cysts in adult polycystic kidney disease

Department of Nephology, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Beedupalli Post, India

Correspondence Address:
Siva V Kumar
Department of Nephology, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthi Gram, Beedupalli Post
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Source of Support: None, Conflict of Interest: None

PMID: 9355697

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How to cite this article:
Kumar SV, Babu KS, Agarwal R, Kumar SB, Lakshmi A Y, Reddy C K. Hepatic cysts in adult polycystic kidney disease. Indian J Med Sci 1997;51:118-9

How to cite this URL:
Kumar SV, Babu KS, Agarwal R, Kumar SB, Lakshmi A Y, Reddy C K. Hepatic cysts in adult polycystic kidney disease. Indian J Med Sci [serial online] 1997 [cited 2016 May 25];51:118-9. Available from:

Adult Potycystic Kidney Disease (APKD) is a multisystem disease with autosomal dominant genetic mediation. Hepatic involvement is one of the important extra-renal manifestation of APKD. The pre­sent study was designed to eva­luate the Hepatic cystic involve­ment in relation to the clinical pre­sentation of PolycysJc Kidneys.

 ¤ Material and Methods Top

Ninety two APKD patients were evaluated by clinical, biochemical, hematological and sonography examination. Patients with hepatic cystic involvement were studied with reference to age, sex, family history, extent of involvement, re­lation to renal failure and presen­tation.

 ¤ Results Top

Ninety two Adult Polycystic Kid­ney Disease Patients were evaluat­ed for hepatic cystic involvement of them 17 (18.5%) were found to have hepatic cysts. Of these 17, twelve (70.6% ) ) were men five (29.4%) were women. 16 had a negative family history for PKD. Mean age in females was 48 yrs and in males 51 yrs. Renal failure was noted in 58.8% of patients with hepatic cystic disease. Jaun­dice was not seen in any one. Vague abdominal pain and mass in abdomen was the presenting sym­ptom in 8 patients (47%).

On an average APKD accounts for approximately 1 in 3000 hospi­tal admissions and 1 in 500 autop­sies. [1] Extrarenal cysts occur in liver in 20 . 50% of Polycystic kid­ney disease [2],[3] and conversely Poly­cys_ic kidneys are found in 20-58% of individuals with polycystic livers. [4] The incidence of hepatic cysts in APKD is reported to be more in the female sex, in the elderly and in those with severe renal disease. [4],[5],[6] Liver cysts are usually asymptomatic but occa­sionally result in obstructive jaun­dice and portal hypertension. Re­garding hepatic cystogenesis gene­tic, hormonal, and circulating cystogenic substances in renal failure are supposed to be respon­sible. [4],[6] The pathophysiology of liver cysts is not well understood. They are thought to originate from Von Meyenburg's complexes (also called biliary micro hemartomas) which are thought to arise from intrahepatic bile ducts which fail to involute. These complexes were found in almost all cases, of cystic liver in adult PKD. [2],[3]

In our study 18.5% of PKD pa­tients had hepatic cysts. Hepatic cysts were more common in men (70.6%) . 58.8% of patients with hepatic cystic disease had renal failure. 47% of the patients with hepatic cysts had abdominal mass and vague pain abdomen as the presenting feature. None had jaundice or portal hypertension. Women presented with hepatic cysts at a lower age (48 yrs) in comparison to men (51 yrs). All the patients of hepatic cystic in­volvement had negative family his­tory for APKD except one.

 ¤ Summary Top

Of ninety two adult polycystic kidney patients 18.5% had liver cysts. Mostly they were multiple. Liver cysts were more common in men.[7]

 ¤ References Top

1.Suki WN. Polycystic kidney dise­ase. Kidney International 1982: 22:571-80.  Back to cited text no. 1      
2.Welling LW. Grantham JJ. Cysts and developmental diseases of the kidney. In : Brenner BN, Rector FC. Ed. The Kidney W.B. Saunders company, Philadelphia, 1991:pp 1657-1694.  Back to cited text no. 2      
3.Zeier M, Gebrerth S, Ritz E, Jaeger T, Waldherr R. Adult domi nant polycystic kidney disease - clinical problems. Nephron 1988: 49:177-83.  Back to cited text no. 3      
4.Gabow PA, Grantham JJ. Polycys­tic kidney disetse. In:Schrier RW, Gottschalk CW, Ed. Diseases of the kidney. Little, Brown and company, Boston, 1993; pp 535-564.  Back to cited text no. 4      
5.Glassberg K. Autosomal dominant polycystic kidney disease. In: Walsh, Retik, Stamey, Baughan, Ed. Campbell's Text Book of Urology. W.B. Saunders company, Philadel­phia 1992; pp 1443-1495.  Back to cited text no. 5      
6.Godela MF, Gabow PA. Hereditary and acquired cystic diseases of the Kidney International 1994;46: 1951-64.  Back to cited text no. 6      
7.Pirson Y, Grunfield JP. Autosomal dominant polycystic kidney disease. In: Cameron S, Davison AM, Grun­field JP, Kerr D, Ritz E, Ed. Oxford­ Text Book of clinical Nephology. Oxford:1992:pp 2171-2188.  Back to cited text no. 7      

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2 Polycystic liver disease and its main complications
Rosenfeld L, Bonny C, Kallita M, et al.


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